Mitochondrial Permeability Transition Pore-as a Promising Target for Novel Neuroprotective Agents
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چکیده
منابع مشابه
Mitochondrial Permeability Transition Pore-as a Promising Target for Novel Neuroprotective Agents
Despite the differences in symptomatic pictures among Neurodegenerative Diseases (ND) all of them result in selective or generalized neuronal loss. The cascade of events leading to the neuronal death is multifactorial. The factors involved include metabolic disturbance, acidosis, excitotoxicity, oxidative stress, neuroinflammation, pathological aggregation of some proteins, and disregulation of...
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In addition to their central role in ATP synthesis, mitochondria play a critical role in cell death. Oxidative stress accompanied by calcium overload, ATP depletion, and elevated phosphate levels induces mitochondrial permeability transition (MPT) with formation of nonspecific MPT pores (MPTP) in the inner mitochondrial membrane. Pore opening results in mitochondrial dysfunction with uncoupled ...
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In addition to their central role in ATP synthesis, mitochondria play a critical role in cell death. Oxidative stress accompanied by calcium overload, ATP depletion, and elevated phosphate levels induces mitochondrial permeability transition (MPT) with formation of nonspecific MPT pores (MPTP) in the inner mitochondrial membrane. Pore opening results in mitochondrial dysfunction with uncoupled ...
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Mitochondrial outer membrane permeabilization (MOMP) is the ultimate step in dozens of lethal apoptotic signal transduction pathways which converge on mitochondria. One of the representative systems proposed to be responsible for the MOMP is the mitochondrial permeability transition pore (MPTP). Although the molecular composition of the MPTP is not clearly understood, the MPTP attracts much int...
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After an episode of myocardial ischemia, opening of the mitochondrial permeability transition pore (mPTP), at the onset of reperfusion, is a critical determinant of myocyte death. We investigated the role of the mPTP as a target for cardioprotection in the human heart. We subjected human atrial tissue, harvested from patients undergoing cardiac surgery, to a period of lethal hypoxia and investi...
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ژورنال
عنوان ژورنال: Journal of Nanomedicine & Biotherapeutic Discovery
سال: 2016
ISSN: 2155-983X
DOI: 10.4172/2155-983x.1000e143